General Information

  • ID:  hor000810
  • Uniprot ID:  Q5DW47
  • Protein name:  Corazonin
  • Gene name:  Crz
  • Organism:  Apis mellifera (Honeybee)
  • Family:  Corazonin family
  • Source:  animal
  • Expression:  In the adult brain, expressed in four neurons of the lateral protocerebrum project axons towards the retrocerebral complex.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Apis (genus), Apini (tribe), Apinae (subfamily), Apidae (family), Apoidea (superfamily), Aculeata (infraorder), Apocrita (suborder), Hymenoptera (order), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005184 neuropeptide hormone activity; GO:0071858 corazonin receptor binding
  • GO BP:  GO:0007218 neuropeptide signaling pathway; GO:0045823 positive regulation of heart contraction
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  QTFTYSHGWTN
  • Length:  11(22-32)
  • Propeptide:  MVNSQILILFILSLTITIVMCQTFTYSHGWTNGKRSTSLEELANRNAIQSDNVFANCELQKLRLLLQGNINNQLFQTPCELLNFPKRSFSENMINDHRQPAPTNNNY
  • Signal peptide:  MVNSQILILFILSLTITIVMC
  • Modification:  T1 Pyrrolidone carboxylic acid;T11 Asparagine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Be involved in the physiological regulation of the heart beat
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  Crzr
  • Target Unid:  B7ZKE3
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-Q5DW47-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor000810_AF2.pdbhor000810_ESM.pdb

Physical Information

Mass: 151994 Formula: C61H80N16O19
Absent amino acids: ACDEIKLMPRV Common amino acids: T
pI: 7.54 Basic residues: 1
Polar residues: 7 Hydrophobic residues: 2
Hydrophobicity: -117.27 Boman Index: -2184
Half-Life: 0.8 hour Half-Life Yeast: 10 min
Half-Life E.Coli: >10 hour Aliphatic Index 0
Instability Index: -522.73 Extinction Coefficient cystines: 6990
Absorbance 280nm: 699

Literature

  • PubMed ID:  16406615
  • Title:  Cloning and Characterization of a Third Isoform of Corazonin in the Honey Bee Apis Mellifera.
  • PubMed ID:  17068263
  • Title:  From the Genome to the Proteome: Uncovering Peptides in the Apis Brain.